Anemia due to chemotherapy
One of the potentials of uses for stimulation and mobilization of stem cells is to fight anemia, which often develops e.g. as a result of chemotherapy.
One study examined the effects of the ingredients of astragalus and angelica (ferulic acid, flavonoids, astragaloside) in mice treated with the chemotherapeutic agent cyclo-phosphamide. As a result of cyclo-phosphamide treatment, the number of red blood cells, platelets and white blood cells and the hemoglobin level drastically decreased, and the area responsible for hematopoiesis in the bone marrow shrunk. The above-listed ingredients from the herbs improved the blood count individually, however their combination improved all of the studied parameters and showed values slightly distinct from the pre-treatment condition.
Examined from a mechanistic point of view, the herbal combination (and the individual substances in varying degrees) also stimulated the self-renewal and proliferation of hematopoietic stem cells, which contributed to rapid regeneration and reversal of treatment-induced stem cell aging.
According to scientific studies, Ganoderma lucidum counteracted the detrimental effects of cyclo-phosphamide and vinerolbine chemo-therapeutic agents on the formation of blood cells in animal experiments.
Not only chemo-therapeutics, heavy metals can also harm the bone marrow. Ingesting spirulina algae helped to prevent the damage to blood cells of lead and cadmium in rats.
- Active Components of Astragali Radix and Angelicae Sinensis Radix Protect Hematopoietic Function Against Cyclophosphamide-Induced Injury in Mice and t-BHP-Induced Injury in HSCs. Front Pharm. 2019; 10:936.
- Effect of recombinant Ganoderma lucidum immunoregulatory protein on cyclophosphamide-induced leukopenia in mice. Immunopharm Immunotox. 2013; 35(3):426-33.
- Immunoactive Compounds of Ganoderma lucidum Spores by Mass Spectrometry Combined With in vivo Zebrafish Assays. Front Pharm. 2020; 11:287.
- Spirulina platensis feeding inhibited the anemia- and leucopenia-induced lead and cadmium in rats. J Hazard Mater. 2009; 164(2-3):1304-9.
When the cerebral blood vessels become blocked, a state of oxygen deficiency, called ischemic stroke may occur. When the blockage is removed, fresh, oxygen-rich blood flows into the tissues, which can unfortunately often further destroy the already damaged brain cells, this is called ischemic/reperfusion injury. When a stroke occurs, the prompt intervention is very important so that neuronal death occurs in as small an area of the brain as possible.
Many herbal ingredients are known to help repair the damaged condition that develops during stroke and subsequent reperfusion. Primarily, as antioxidants, they protect neurons and tissue stem cells from reactive oxygen-radicals, which is caused by oxidative stress from re-supplying oxygen to the damaged brain area. In addition, a number of plant agents have been shown to be able to stimulate neural progenitors and neural stem cells to divide and perform neurogenesis, thus improving brain regeneration and supporting recovery.
Such herbal substances are astragalosides of astragalus root, proanthocyanidins in grape seeds, fucoidan from brown algae, but the consumption of spirulina algae or the linghzi mushroom is also a beneficial effect resulted in animal studies. The mitigation of ischemic/reperfusion damage may be supported by vitamin E, coenzyme Q10 and the rutin flavonoid, reducing the deteriorating effect of oxidative stress and pro-inflammatory cytokines.
- Astragaloside IV Exerts Cognitive Benefits and Promotes Hippocampal Neurogenesis in Stroke Mice by Downregulating Interleukin-17. Front Pharm. 2020; 11:421.
- Astragaloside VI Enhances Neurological Function Recovery in Transient Cerebral Ischemic Injury. Mol Neurobiol. 2019; 56(4):3053-3067.
- Neuroprotective effect of Ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus. Neural Regen Res. 2014; 9(15):1446-52.
- Metabolites from the mushroom Ganoderma as stimulators of neural stem cell proliferation. Phytochem. 2015; 114:155-62.
- Grape seed proanthocyanidins attenuate apoptosis in ischemic stroke. Acta Neurol Belg. 2019; doi: 10.1007/s13760-019-01111-9.
- Neuroprotective effect of Spirulina in cerebral ischemia-reperfusion injury in rats. J Neural Transm. 2010; 117(9):1083-91.
- Leukocyte-platelet aggregates in rat peripheral blood after ischemic stroke and reperfusion. Biol Res Nurs. 2005; 6(4):281-8.
- Possible role of vitamin E, coenzyme Q10 and rutin in protection against cerebral ischemia/reperfusion injury in irradiated rats. Int J Radiat Biol. 2010; 86(12):1070-8.
Fucoidan can increase the regenerative capacity of the body by stimulating stem cells. In an experiment with mice, fucoidan was able to mobilize vascular wall stem cells and cardiac stem cells (scientifically known as endothelial and cardiac progenitors). Their number increased by 70% and by 25%, respectively. This elevated stem cell count helped to maintain normal vascularization of a transplanted organ, and new artery wall cells were formed to replace the dead cells in the inflamed vessel wall. The stem cell mobilizing effect of fucoidan was observed also for humans.
You can read more about the artery wall protective effect of fucoidan in the following post:
FUCOIDAN: STEM CELL MOBILIZATION AND ARTERY WALL PROTECTION